Table 1.
Selected nutraceuticals tested against HCC cells*
| Nutraceutical | Major functions | Reference | HCC-effective concentrations | xMAP assay selected concentrations |
|---|---|---|---|---|
| QUE (flavonol) | • antioxidant | 10, 21 | 10–50 μM | 25 μM |
| • antiproliferative | ||||
| • anti-inflammatory | ||||
| • antimetastatic | ||||
| POH (monoterpene) | • antiproliferative | 22 | 0.25–1 mM | 500 μM |
| • anti-inflammatory | ||||
| • proapoptotic | ||||
| • antiangiogenic | ||||
| FIS (flavonol) | • antiproliferative | 10 | 10–50 μM | 10 μM |
| • anti-inflammatory | ||||
| • antioxidant | ||||
| • antiangiogenic | ||||
| CUR (polyphenol) | • anti-inflammatory | 10 | 10–25 μM | 15 μM |
| • antioxidant | ||||
| EGCG (polyphenol) | • anti-inflammatory | 23–24 | 50–200 μM | 50–200 μM |
| • antioxidant | ||||
| • antiproliferative | ||||
| • antiangiogenic | ||||
| ERI (flavonone) | • anti-inflammatory | 25 | 10–50 μM | 25 μM |
| • antioxidant | ||||
| • antiproliferative | ||||
| NAR (flavonone) | • antiproliferative | 21 | 10–200 μM | 100 μM |
| • anti-inflammatory | ||||
| • proapoptotic |
*
A complete list of tested nutraceuticals is shown in Supplementary Table S1.