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. Author manuscript; available in PMC: 2015 Jul 17.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1126–1135. doi: 10.1167/iovs.07-1234

Figure 8.

Figure 8

Retinal histology and thickness measurements in Rpe65−/−/Nrl−/−, single-knockout, and wild-type mice at 4, 7, and 12 weeks of age. (A) Phase-contrast micrographs of toluidine-stained RPE/retina sections. ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. CI, central retina inferior to optic nerve head; CS, central retina superior to optic nerve head. (B, C) Plots of ONL thickness in Rpe65−/−/Nrl−/− and wild-type mice, with measurements made on sections parallel (superior, inferior) and orthogonal (nasal, temporal) to the vertical meridian of the eye with standard deviations shown: 4 weeks (▲); 7 weeks (∎); 12 weeks (∎).