Table 2. PDSP Screening Affinities for All Compounds at Other Human Serotonin Receptor Typesa.
| cmpd | 5-HT2B | 5-HT1A | 5-HT1B | 5-HT1D | 5-ht1e | 5-HT3 | 5-ht5a | 5-HT6 | 5-HT7 |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 8.86 ± 0.03 (1.4) | 5.99 ± 0.05 (1033) | 5.23 ± 0.06 (5886) | 6.27 ± 0.05 (533) | >10,000 | >10,000 | 5.55 ± 0.07 (2795) | 7.5 ± 0.06 (32) | 5.81 ± 0.06 (1542) |
| 4a | 8.34 ± 0.03 (4.6) | 6.03 ± 0.05 (925) | 5.49 ± 0.05 (3232) | 6.36 ± 0.05 (439) | 5.77 ± 0.05 (1707) | >10,000 | 7.24 ± 0.06 (57) | 7.17 ± 0.06 (67) | 6.23 ± 0.06 (583) |
| 4b | 7.78 ± 0.03 (17) | 5.97 ± 0.05 (1064) | 5.8 ± 0.05 (1592) | 6.49 ± 0.05 (325) | 5.89 ± 0.05 (1285) | >10,000 | 5.99 ± 0.06 (1020) | 7.12 ± 0.03 (75) | 5.8 ± 0.06 (1575) |
| 4c | 7.7 ± 0.04 (20) | 5.94 ± 0.06 (1155) | >10,000 | 6.37 ± 0.05 (423) | >10,000 | >10,000 | 5.64 ± 0.09 (2290) | 6.59 ± 0.06 (257) | 5.59 ± 0.05 (2547) |
| 4d | 7.89 ± 0.04 (13) | 6.17 ± 0.06 (670) | 5.80 ± 0.05 (1568) | 6.79 ± 0.05 (162) | 6.10 ± 0.04 (792) | >10,000 | 6 ± 0.08 (1009) | 6.76 ± 0.06 (175) | 6.45 ± 0.05 (355) |
| 4e | 7.17 ± 0.04 (68) | 6.19 ± 0.06 (649) | 5.22 ± 0.05 (5093) | 6.51 ± 0.05 (311) | >10,000 | 5.61 ± 0.05 (2460) | 5.73 ± 0.06 (1848) | 6.46 ± 0.05 (350) | 6.19 ± 0.05 (641) |
| 5a | 8.04 ± 0.03 (9) | 6.64 ± 0.05 (231) | >10,000 | 5.89 ± 0.05 (1292) | >10,000 | >10,000 | >10,000 | 7.06 ± 0.03 (87) | 5.75 ± 0.06 (1770) |
| 5b | 8.6 ± 0.03 (2.5) | 6.48 ± 0.05 (335) | >10,000 | 6.48 ± 0.06 (334) | >10,000 | >10,000 | 5.9 ± 0.06 (1261) | 7.6 ± 0.03 (25) | 6.39 ± 0.05 (406) |
| 5c | 7.49 ± 0.03 (33) | 7.12 ± 0.06 (76) | 5.97 ± 0.04 (1060) | 6.79 ± 0.06 (161) | >10,000 | >10,000 | 5.62 ± 0.09 (2388) | 6.45 ± 0.03 (353) | 7.44 ± 0.05 (37) |
| 5d | 7.62 ± 0.03 (24) | 6.54 ± 0.05 (286) | >10,000 | 6.11 ± 0.05 (782) | >10,000 | 5.21 ± 0.07 (6169) | >10,000 | 6.69 ± 0.05 (203) | 5.96 ± 0.05 (1086) |
| 5e | 8.45 ± 0.03 (3.6) | 6.81 ± 0.05 (155) | 5.19 ± 0.06 (6433) | 6.42 ± 0.05 (381) | >10,000 | >10,000 | 6.21 ± 0.06 (612) | 7.34 ± 0.03 (45) | 6.93 ± 0.06 (116) |
| 5f | 6.83 ± 0.03 (150) | 7.11 ± 0.05 (78) | 5.35 ± 0.05 (4374) | 6.57 ± 0.05 (271) | >10,000 | >10,000 | 5.99 ± 0.08 (1034) | 6.25 ± 0.03 (566) | 6.45 ± 0.06 (358) |
| 5g | 7.66 ± 0.03 (22) | 6.53 ± 0.04 (295) | 5.57 ± 0.06 (2674) | 6.50 ± 0.06 (319) | >10,000 | >10,000 | 5.61 ± 0.05 (2450) | 7.23 ± 0.03 (59) | 6.62 ± 0.05 (242) |
| 5h | 8.16 ± 0.02 (6.6) | 6.71 ± 0.05 (195) | 5.36 ± 0.06 (4392) | 6.55 ± 0.06 (282) | >10,000 | >10,000 | 5.64 ± 0.06 (2310) | 7.30 ± 0.03 (50) | 6.55 ± 0.05 (281) |
| 5i | 9.12 ± 0.03 (0.76) | 6.91 ± 0.05 (122) | 5.53 ± 0.05 2963) | 6.70 ± 0.06 (199) | >10,000 | >10,000 | 5.81 ± 0.05 (1536) | 7.58 ± 0.03 (27) | 7.66 ± 0.05 (22) |
| 5j | 8.71 ± 0.03 (1.9) | 6.57 ± 0.04 (271) | 5.37 ± 0.07 (4241) | 6.55 ± 0.06 (283) | 5.41 ± 0.05 (3876) | >10,000 | 5.41 ± 0.06 (3852) | 7.21 ± 0.03 (62) | 6.67 ± 0.05 (212) |
| 5k | 7.56 ± 0.02 (28) | 6.62 ± 0.05 (240) | >10,000 | 6.56 ± 0.06 (278) | >10,000 | >10,000 | 5.51 ± 0.06 (3091) | 7.06 ± 0.03 (87) | 6.58 ± 0.05 (262) |
| 5l | 8.39 ± 0.04 (4.1) | 6.90 ± 0.05 (127) | >10,000 | 6.18 ± 0.05 (659) | >10,000 | >10,000 | 6.08 ± 0.08 (841) | 8.01 ± 0.06 (9.7) | 6.87 ± 0.05 (136) |
a
pKi ± SEM, (affinity in nM).