Table 3. Stratification analyses of NBS1 Polymorphism with CRC risk in the discovery set.
| Variables | Cases (763) | Controls (892) | Adjusted OR (95% CI) a | P value b | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GG+GC(N) | (%) | CC(N) | (%) | GG+GC(N) | (%) | CC(N) | (%) | GG+GC VS CC | ||
| Age (years) | ||||||||||
| ≤60 | 304 | (39.84) | 121 | (15.86) | 389 | (43.61) | 109 | (12.22) | 1.42 (1.07–1.93) | 0.29 |
| >60 | 285 | (37.35) | 53 | (6.95) | 359 | (40.25) | 35 | (3.92) | 1.92 (1.22–2.98) | |
| Sex | ||||||||||
| Male | 301 | (39.45) | 95 | (12.45) | 386 | (43.27) | 92 | (10.31) | 1.92 (1.30–2.80) | 0.15 |
| Female | 288 | (37.75) | 79 | (10.35) | 362 | (40.58) | 52 | (5.83) | 1.33 (0.97–1.83) | |
| Smoking Status | ||||||||||
| Positive | 250 | (32.77) | 106 | (13.89) | 301 | (33.74) | 98 | (10.99) | 1.96 (1.31–2.91) | 0.12 |
| Negative | 339 | (44.43) | 68 | (8.91) | 447 | (50.11) | 46 | (5.16) | 1.30 (0.95–1.81) | |
| Drinking Status | ||||||||||
| Positive | 199 | (26.08) | 130 | (17.04) | 284 | (31.84) | 89 | (9.98) | 2.09 (1.51–2.88) | 0.004 |
| Negative | 390 | (51.11) | 44 | (5.77) | 464 | (52.02) | 55 | (6.17) | 0.95 (0.64–1.45) | |
| Body Mass Index | ||||||||||
| ≤20 | 129 | (16.91) | 42 | (5.50) | 157 | (17.60) | 41 | (4.60) | 1.24 (0.77–2.02) | 0.43 |
| 20< BMI < 28 | 433 | (56.75) | 108 | (14.15) | 546 | (61.21) | 75 | (8.41) | 1.82 (1.32–1.50) | |
| ≥28 | 27 | (3.54) | 24 | (3.15) | 45 | (5.04) | 28 | (3.14) | 1.43 (0.70–2.94) | |
| Family history of cancer c | ||||||||||
| Positive | 31 | (4.06) | 32 | (4.19) | 42 | (4.71) | 38 | (4.26) | 1.14 (0.58–2.22) | 0.28 |
| Negative | 558 | (73.14) | 142 | (18.61) | 706 | (79.15) | 106 | (11.88) | 1.69 (1.29–2.21) | |
| TNM stage | ||||||||||
| I/II | 318 | (41.68) | 76 | (9.96) | 748 | (83.86) | 144 | (16.14) | 1.62 (1.22–2.13) | 0.59 |
| III/IV | 271 | (35.52) | 98 | (12.84) | 748 | (83.86) | 144 | (16.14) | 1.46 (1.03–1.96) | |
aAdjusted for age, sex, BMI, smoking status, drinking status and family history of CRC as appropriate in a logistic regression model.
b P value of the test for homogeneity between stratum-related ORs for NBS1 (rs2735383GG+GC versus CC genotypes), the values of which were presented in bold, was defined as statistically significant.
cFamily history of cancer represents a history of all malignant tumors in first-degree relatives, which included fathers, mothers, brothers and sisters.