Table 3.
Reported STAT6 Expression in Mesenchymal and Spindle Cell Neoplasms.
| Tumor type | Total number | STAT6 Positive† | % Positive |
|---|---|---|---|
| Solitary fibrous tumor | 208 | 204 | 98% |
| Tumors of the central nervous system | |||
| Glioblastoma | 10 | 0 | 0 |
| Gliosarcoma* | 12 | 0 | 0 |
| Hemangioblastoma | 12 | 0 | 0 |
| Meningeal sarcoma/unclassified meningeal tumor | 7 | 4 | 57% |
| Meningioma* | 98 | 0 | 0 |
| Tumors of the pleura/ lung/ mediastinum | |||
| Sarcomatoid lung carcinoma* | 5 | 0 | 0 |
| Sarcomatoid mesothelioma* | 14 | 0 | 0 |
| Synovial sarcoma* | 86 | 0 | 0 |
| Thymoma (type A)* | 2 | 0 | 0 |
| Adipocytic tumors | |||
| Dedifferentiated liposarcoma* | 134 | 12 | 9% |
| Myxoid liposarcoma | 46 | 1 | 2% |
| Pleomorphic liposarcoma | 11 | 0 | 0 |
| Spindle cell lipoma* | 14 | 0 | 0 |
| Well-differentiated liposarcoma | 10 | 0 | 0 |
| Aggressive/ malignant tumors of soft tissue | |||
| Dermatofibrosarcoma protuberans* | 40 | 0 | 0 |
| Desmoid tumor* | 41 | 0 | 0 |
| Extraskeletal myxoid chondrosarcoma | 9 | 0 | 0 |
| Gastrointestinal stroma tumor* | 56 | 0 | 0 |
| Leiomyosarcoma* | 39 | 0 | 0 |
| Low grade endometrial stroma sarcoma* | 4 | 0 | 0 |
| Low grade fibromyxoid sarcoma* | 23 | 2 | 9% |
| Low grade myofibroblastic sarcoma | 18 | 0 | 0 |
| Malignant peripheral nerve sheath tumor | 70 | 0 | 0 |
| Mesenchymal chondrosarcoma | 6 | 0 | 0 |
| Myxofibrosarcoma | 8 | 0 | 0 |
| Undifferentiated pleomorphic sarcoma* | 140 | 2 | 1% |
| Alveolar soft part sarcoma | 8 | 0 | 0 |
| Angiosarcoma | 12 | 0 | 0 |
| Clear cell sarcoma | 4 | 0 | 0 |
| Epithelioid sarcoma | 8 | 0 | 0 |
| Ewing sarcoma* | 6 | 0 | 0 |
| Benign soft tissue tumors | |||
| Cellular angiofibroma | 10 | 0 | 0 |
| Dermatofibroma/benign fibrous histiocytoma* | 26 | 1 | 4% |
| Desmoplastic fibroblastoma | 5 | 0 | 0 |
| Fibroma of tendon sheath | 4 | 0 | 0 |
| Hemangioma | 25 | 0 | 0 |
| Leiomyoma of deep soft tissue* | 2 | 0 | 0 |
| Myofibroma/myopericytoma* | 5 | 0 | 0 |
| Neurofibroma | 4 | 0 | 0 |
| Nodular fasciitis* | 66 | 1 | 2% |
| Ovarian fibroma* | 2 | 1 | 50% |
| Schwannoma* | 43 | 0 | 0 |
| Sinonasal glomangiopericytoma | 6 | 0 | 0 |
| Soft tissue angiofibroma* | 1 | 0 | 0 |
| Soft tissue perineurioma* | 15 | 0 | 0 |
| Total non-solitary fibrous tumors | 1167 | 24 | 2% |
†
Positive STAT6 expression was defined as strong nuclear expression in the absence of cytoplasmic staining.
*
Indicates tumors for which combined nuclear/cytoplasmic positivity has been reported. Not all reports distinguished between this pattern and negative stain.