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. 2015 Jun 17;195(3):841–852. doi: 10.4049/jimmunol.1403063

FIGURE 7.

FIGURE 7.

Blocking CXCR2 signaling lessens atypical EAE development by reducing neutrophil infiltration into the CRB and BS. (A) LysMCre-SOCS3fl/fl mice were administered 200 μg SB 225002 (n = 4) or vehicle control (n = 5) i.p. once per day from days 3 to 7 postimmunization and twice per day from days 8 to 14. The incidence of different EAE phenotypes was compared between the vehicle control and SB 225002-treated groups. (B) Mean ± SD of atypical EAE scores. Atypical EAE scores were compared between vehicle control and SB 225002 groups at the indicated time points. (C) Graph illustrating quantitative data for absolute numbers of total infiltrating mononuclear cells in the CRB, BS, and SC from LysMCre-SOCS3fl//fl mice treated with vehicle control or SB 225002 at day 17 postimmunization. Mean ± SD. (D) Graph illustrating quantitative data for percentage of accumulated neutrophils in total CNS-infiltrating cells from CRB, BS, and SC from LysMCre-SOCS3fl//fl mice treated with vehicle control or SB 225002 at day 17 postimmunization. Mean ± SD. *p < 0.05, **p < 0.01.