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. 2015 Jun 19;195(3):882–891. doi: 10.4049/jimmunol.1403110

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Copyright © 2015 The Authors

This is an open-access article distributed under the terms of the CC-BY 3.0 Unported license.

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FIGURE 7. — MT1-MMP is necessary for M. tuberculosis–driven monocyte migration. (A and B) Light microscopy images show migrating monocytes forming clusters around the CoMTb drop at 24 h. (C) Neutralization of MT1-MMP activity with an inhibitory anti–MT1-MMP Ab reduces monocyte migration. (D) An isotype control Ab did not affect cellular migration. (E) The maximum diameter of the monocyte clusters were analyzed, with images taken at four radial points per bead. Quantification confirms reduced monocyte migration with MT1-MMP neutralization. Data are means ± SD from a single experiment and are representative of two independent experiments. ***p < 0.001 by one-way ANOVA with a Tukey post hoc test.