Table 5.

Clinical trial pharmacokinetic results of IP paclitaxel instillation therapy

Study	Year	Paclitaxel delivery method	Dose	Cmax_IP (μmol/L)a	T max_IP (hours)	Cmax_IP/ $C_{\text{max}\_\text{plasma}}^{\text{a}}$	AUCIP/ ${\text{AUC}}_{\text{plasma}}^{\text{a}}$
Markman [33]	1992	Instillation IP chemotherapy	25–175 mg/m2/3–4 weeks	175b	0.5–1	~1000	996d
Francis [31]	1995	Instillation IP chemotherapy	30–75 mg/m2/week	50–1273c	0.5–2
Hofstra [34]	2002	Instillation IP chemotherapy	75 mg/m2 D1 + 8/4 week				1350d
Mohamed [35]	2003	Instillation IP chemotherapy	20 mg/m2/day for 5 days	~45	0.25	~800
deBree [12]	2008	HIPEC	175 mg/m2 for 2 h	118	0.08	1178	1462 for 2 h (366  total for 5 days period)
Nanotax®	2014	Instillation IP chemotherapy	50–275 mg/m2/4 weeks	1–61c	56	1168

^aMean values

^bMean value for 50–175 mg/m² range

^cRange, not mean value

^dFor the duration of IP instillation chemotherapy