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. 2015 Jul 17;10(7):e0133220. doi: 10.1371/journal.pone.0133220

Fig 1. Immunological characteristics of patients with hypomorphic RAG deficiency and impaired antibody production against bacterial polysaccharide antigens.

Fig 1

Patient A…circles; patient B…triangles 22 (A) Impaired antibody production against bacterial polysaccharide antigens in RAG-deficient patients. Box-plots represent pn23-antibodies in 41 healthy individuals (B) Numbers of CD4+CD45RA+ (naïve CD4) and CD8+CD45RA+CD62L+ (naïve CD8) T cells given as percentage of total CD8- or CD4-positive T cells. Box-plots depict 50 healthy individuals (C) Kinetic of the total count of CD4+ T cells and naïve CD4+CD45RA+ T cell depicted as average of both patients (D) Representative example of the distribution of TCR Vbeta genes 16, 17, 18, 22 (E) Numbers of switched memory B cells given as percentage of total CD19 B cells. Box-plots depict 50 healthy individuals (F) Numbers of CD21low B cells given as percentage of total CD19 B cells. Box-plots depict 50 healthy individuals (median,+; box, IQR; whiskers, q5-q95).