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. 2015 Jul 17;10(7):e0133414. doi: 10.1371/journal.pone.0133414

Fig 1. ATRA protects mice from I/R-induced cardiac injury.

Fig 1

Images show transverse, TTC-stained sections of mouse hearts from I/R, ATRA+I/R, RKO-I/R, and ATRA+RKO-I/R groups. After I/R injury, the infarct areas were significantly smaller in ATRA+I/R group than in I/R group (n = 3 in each group). The protective role of ATRA on myocardial I/R injury was not observed in RAGE-KO mice, as the infarct areas did not differ between RKO-I/R and ATRA+RKO-I/R group (n = 3 in each group). Data is expressed as mean ± SD (# P<0.05 vs. I/R group).