Table 2.

Homocysteine induces platelet aggregation

Hey concentration (μm)	Lag-time (sec.)	% rate	% aggregation
Platelets from healthy donors
50	689.8 ± 141.5	52.6 ± 4.0	79.0 ± 3.6
100	715.1 ± 116.2	62.0 ± 6.9	67.2 ± 4.1
200	990.2 ± 168.1	41.0 ± 1.9	60.2 ± 5.1
Platelets from type 2 diabetic patients
50	1054.9 ± 220.7*	48.0 ± 3.5	86.8 ± 1.5*
100	1316.3 ± 223.9*	51.5 ± 7.6	76.4 ± 3.7*
200	1593.8 ± 307.4*	45.8 ± 2.4*	71.8 ± 4.8*

Human platelets were suspended in a HBS containing 1 mM Ca²⁺ and then were treated at 37°C with increasing concentrations of homocys-teine and platelet aggregation was induced at a shear rate of 1200 rpm at 37°C. Values given are presented as mean ± S.E.M. of 11 separate determinations. ^*P < 0.05 compared to the response in platelets from healthy donors.