Effects of NADPH oxidase inhibitors apocynin and gp91ds-tat on angiogenesis in the chamber in vivo. (A, panels A, B) lectin staining of sections from the 14-day samples without (panel A) and with (panel B) apocynin (10 mM) treatment, (panel C) H&E staining showing that the apocynin-containing Matrigel (the pink matrix) did not prevent the infiltration of inflammatory cells prior to vessel development in unorganized areas, (panel D) higher magnification of the outlined area in panel C. (b) Quantitative data of the vessel density (% area) in control and apocynin-treated chamber tissues at 7 and 14 days. The vessel density was assessed in an area as outlined in panels A & B. * P<0.05 versus control, unpaired t-test, n = 5. (c) Effects of gp91ds-tat (100 μM) on neovascularization. A scrambled peptide was used as control. * P < 0.005 versus control, unpaired t-test, n = 5.