Table 1.

Metabolic parameters of 3- and 6-months-old WT and Tg972 mice fed either ND or- FD.

	WTi nice				Tg972 mice
	3mND	6mND	3 m HFD	6 m HFD	3mND	6mND	3 m HFD	6 m HFD
Fed glucose (mg/dl)	120 ± 30	140 ± 20	213 ± 28	320 ± 45	132 ± 42.92	165 ± 43#	232 ± 27§	370 ± 65*
	(n = 30)	(n = 25)	(n = 19)	(n = 12)	(n = 25)	(n = 30)	(n = 17)	(n = 10)
Fed Insulin (ng/ml)	1.1 + 0.25	1.2 ± 0.6	2.41 + 0.51	3.1 ± 0.45	0.95 ± 0.43	0.75 ± 0.4†	3.41 + 1.07 §	2.6 ± 0.4*
	(n = 20)	(n = 15)	(n = 10)	(n = 7)	(n = 22)	(n = 12)	(n = 9)	(n = 7)
Fasting glucose (mg/dl)	75 ± 21	85 ± 22	114 + 31	120 ± 22	82 ± 20	115 + 34#	137 ± 39§	160 ± 17°
	(n = 45)	(n = 20)	(n = 21)	(n = 11)	(n = 40)	(n = 28)	(n = 27)	(n = 8)
Fasting insulin (ng/ml)	0.65 ± 014	0.75 ± 0.4	1.96 ± 0.34	2.2 ± 0.4	0.55 ± 0.4	0.52 ± 0.4	2.1 ± 0.34	1.4 ± 0.3Λ
	(n = 15)	(n = 18)	(n = 10)	(n = 6)	(n = 17)	(n = 16)	(n = 12)	(n = 7)

Samples were collected in fed or overnight fasted male mice. Data are expressed as mean ± SD.

^#P < 0.01,

^†P < 0.05 for ND Tg972 mice versus ND WT mice at 6 months of age,

^§P < 0.05 for HFD Tg972 mice versus HFD WT mice at 3 months of age,

^*P < 0.05,

^{^}P < 0.01,

^°P < 0.0001 for HFD Tg972 mice versus HFD WT mice at 6 months of age by Student's t-test.