Figure 6. Physiologically relevant action potential waveforms have significant CDF.

A, parameters of channel model illustrated in Fig.5A in the unfacilitated and facilitated states. B and C, Ca_V2.1 E3A permeating Li⁺ currents are triggered by action potential waveforms recorded from cerebellar Purkinje neurons. Stimulated currents are steady at baseline Ca²⁺ (C, left). Ca²⁺ uncaging in the midst of the ∼50 Hz train causes large enhancement of Li⁺ current (C, right). An expanded view of traces before and after Ca²⁺ elevation (black) are shown in B, with simulation results overlaid (red). D and E, population data (mean ± SEM) for peak Li⁺ current as a function of time with n = 5 cells.