Figure 2. tLTP induced by 10 pairings is NMDAR independent.

A and B, tLTD induced with 100 (A) or 50 (B) pre–post pairings is CB₁R mediated. 100 and 50 pre–post pairings induced a potent tLTD (n = 7 and 7, respectively), which was prevented by AM251 treatment (3 μm, n = 5 and 7, respectively). C, tLTP induced with 10 post–pre pairings was not prevented by d-AP5 (50 μm, n = 13), indicating that this tLTP was not NMDAR mediated. Summary bar graphs illustrating that tLTP induced by 100 post–pre pairing is NMDAR mediated since it is prevented by d-AP5 treatment, while tLTP induced by 10 post–pre pairings is NMDAR independent. Representative traces are the average of 15 EPSCs during baseline recording (black traces) and 50 min after STDP protocol (grey traces). Error bars represent SD. *P < 0.05; ns, not significant.