Figure 6. eCB-tLTP is induced in both striatopallidal and striatonigral MSNs and is dopamine dependent.
A, tLTP induced by 15 pairings is observed in both striato-pallidal (D1-eGFP positive neurons, D1+, n = 7) and striato-nigral (D1-eGFP negative neurons, D1–, n = 9) MSNs. B, co-application of antagonists of D1R and D2R, SCH23390 (4 μm) and sulpiride (10 μm), prevents eCB-tLTP (n = 7). C, tLTP was induced in presence of the D1R antagonist SCH23390 (4 μm, n = 7), while no plasticity was observed with the D2R antagonist sulpiride (10 μm, n = 6). Representative traces are the average of 15 EPSCs during baseline recording (black traces) and 40 (A) and 50 (B and C) min after STDP protocol (grey traces). Error bars represent SD.