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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Neuron. 2015 Jun 25;87(2):341–354. doi: 10.1016/j.neuron.2015.06.007

Figure 6. Sensory neurons control ILC2 and CD4+ cell recruitment and activation in the lung.

Figure 6

On day 16 (A–F), OVA-exposed mice (pink bars) with intact nociceptors (littermate; NaV1.8−/−DTA+/−) had higher whole lung CD45+ (A), CD4+ (B), ILC2 (C), ILC2 IL-13+ cell counts (D), as well as ILC2 CD25 (E) and ST2 mean fluorescence intensity MFI) (F) than mice with ablated nociceptors (NaV1.8+/−DTA+/−). QX-314 treatment (100 μM, day 18; blue squares) decreased OVA-induced CD4+ cells on day 21 (G), including CD4+IL5+ (H) and CD4+IL13+ (I) cells, relative to control mice (white squares). Mean ± S.E.M; Two-tailed unpaired student’s t-test (n = 4–9 animals/group; 1–2 cohorts).