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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Clin Cancer Res. 2015 Apr 7;21(14):3149–3159. doi: 10.1158/1078-0432.CCR-14-1421

Figure 2. Assessment of liver inflammation and injury following anti-CEA CAR-T HAIs.

Figure 2

(A) Normal liver biopsies were obtained under CT guidance prior to the first infusion and just prior to the third infusion. Routine H&E staining is shown. (B) Alkaline phosphatase, total bilirubin, and aspartate aminotransferase levels are shown for the patients who did not or did receive systemic IL2. Dotted vertical lines indicate CAR-T infusion time points and the first data point represents the baseline value prior to CAR-T infusion. Platelet counts (C) and INR values (D) for each patient are shown.