Figure 3. FAP-CAR T cells restrict tumor growth through decreasing stromagenesis and tumor angiogenesis in desmoplastic human lung cancer xenografts.

Established A549 tumor-bearing mice were either injected i.v with FAP-CAR human T cells or left untreated. Tumors were harvested 8 days post-adoptive T cell transfer. Tumor sections were stained with antibodies against FAP (A) and α-SMA (B) to examine the degree of stromagenesis. Tumor tissues were stained with antibodies against CD31 (C) and NG2 (D) to reveal endothelium and pericytes, respectively. * Denotes statistical significance between untreated and FAP-CAR T cell-treated samples (n=3), p value < 0.01. Scale: 100 μm.