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. 2015 Jun 19;6(8):553–561. doi: 10.1007/s13238-015-0176-y

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Hierarchy model of cardiovascular specification from pluripotent stem cells. During stem cell differentiation, Brachyury T expression marks the precardiac mesodermal cells; Mesp1-expressing cells represent early multipotent cardiovascular progenitors; Nkx2-5 and Islet1 reporter genes are used for isolating cardiovascular progenitors of the first (Nkx2-5) and the second heart fields (Nkx2-5 and Islet1). Finally, cardiovascular progenitors give rise to all three lineages of the heart: cardiomyocytes, endothelial cells, and smooth muscle cells