Fig. 7.

Toll-like receptor agonists. (a) Deprotection of the photocaged agonist in the presence of light causes TLR7/8 activation and subsequent signaling. Reprinted with permission from Ryu et al., J. Am. Chem. Soc. 136, 10823 (2014). Copyright 2014, American Chemical Society. (b) Synergistic combination of agonists on the surface of a tumor cell, LTA for TLR2/6 and CpG-oligonucleotides for TLR9, causes enhanced stimulation in immune cells. Reproduced with permission from Tom et al., Chem. Commun. 49, 9618 (2013). Copyright 2013, the Royal Society of Chemistry.