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. 2015 Jun 14;2(6):596–606. doi: 10.18632/oncoscience.171

Figure 5. FFPE sections of U251 spheroids displaying differential staining intensities in cells contained within the core and migratory cells after treatment.

Figure 5

(A) Graphic illustration of staining patterns and intensities observed for SOX-2 expression in core maintained cells and migratory cells. (B) SOX-2 antigen staining in spheroid core cells and migratory cells after no treatment (Medium), 20 mM LiCl, 5 μM BIO, x10 magnification. Corresponding images at x40 magnification show SOX-2 expression in invading cells and cells maintained within the core with treated specimens (bottom row). In treated cells SOX-2 levels are higher in migratory cells than in the cells maintained within the core.