Fig. 4.

Effects of PD98059 on melanin synthesis (A) and cellular tyrosinase activity (B) in ginsenoside Rg3 (G-Rg3)-treated B16F10 cells. Cells were exposed to 200nM alpha-melanocyte-stimulating hormone (α-MSH) after pretreatment with or without G-Rg3 (60μM) and PD98059 (20μM). Each treated cell is reported as a percentage relative to that in α-MSH-treated control cells. Data are reported as the mean ± standard error of the mean of three independent experiments carried out in triplicate. * p < 0.05 compared with α-MSH and G-Rg3 co-treated cells.