Table 3. Multivariable Cox regression analysis in untreated and treated patients with ERBB2+ tumours (total number=160, unfavourable events=56 and missing values=7).
| Variables | β | HR (95% CI) | P-value |
|---|---|---|---|
| hsa-miR-30e* (continuous) | −0.674 | 0.510 (0.288–0.903) | 0.0209 |
| Age (>50 years, ≤50 years) | −0.231 | 0.794 (0.445–1.415) | 0.434 |
| Size (>2 cm, ≤2 cm) | 0.551 | 1.730 (0.888–3.389) | 0.107 |
| Grade (3, 1–2) | 0.097 | 1.100 (0.567–2.140) | 0.775 |
| Lymph node (+, −) | 1.038 | 2.820 (1.264–6.302) | 0.0113 |
| Treatment (yes, no) | 0.103 | 1.110 (0.432–2.847) | 0.83 |
| T-cell metagene (+, −) | −0.37 | 0.691 (0.383–1.245) | 0.219 |
| IFN metagene (+, −) | −9.013 | 0.000122 (0–0.332) | 0.0255 |
| hsa-miR-30e* : IFN metagene | 1.154 | 3.170 (1.197–8.395) | 0.0202 |
Abbreviations: CI=confidence interval; GGI=Genomic Grade Index; HR=hazard ratio; IFN=interferon. P-values under the threshold for statistical significance are reported in bold.