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. 2015 Jun 23;113(2):242–251. doi: 10.1038/bjc.2015.228

Figure 5.

Figure 5

Inhibition of survivin and MAOA achieved synergistic inhibition of PCa cell migration. (A) MAOA and survivin exhibit significantly higher expression in metastatic PCa compared to primary site PCa. Oncomine was used for data analysis (Yu et al, 2004). Upper: heat map of MAOA and survivin expression in primary site and metastatic PCa. Lower: statistical analysis of MAOA and survivin (BIRC5) expression in primary site and metastatic PCa. (B) Effects of combination treatment with SC144 and clorgyline on cell migration. LNCaP cells were treated with 0.1 μM SC144 or/and 2 μM clorgyline. Left: one of three representative experiments is shown. Right: statistical analysis of the migration data. Bars represent s.e.m. P=0.003. (C) Effects of combination treatment with SC144 and clorgyline on MMP-9 expression in LNCaP cells. Cells were treated with 0.5 μM SC144 and/or 2 μM clorgyline for 48 h, followed by western blotting analysis. Upper: one of two representative experiments is shown. Lower: statistical analysis of the western blotting data. Bars represent s.e.m. (D) Effects of SC144 (0.5 μM)/clorgyline (μM) combination on LNCaP cell invasion through the Boyden chamber inserts coated with Matrigel. Bars represent s.e.m.