Table 2. Summary odds ratios for the association between combined MC1R variants and non-melanoma skin cancer and heterogeneity estimates.
|
All studies |
Sequenced studies only |
|||||
|---|---|---|---|---|---|---|
| Variant | N studies (N cases/N controls) | SOR (95%CI) | Q-test P-value | I2 (%) | N studies (N cases/N controls) | SOR (95%CI) |
|
All | ||||||
| Wild typea | 8 (1162/4419) | Reference | — | — | 4 (360/539) | Reference |
| Any variant | 8 (2365/4972) | 1.48 (1.24–1.76) | 0.01 | 60.5 | 4 (1074/884) | 1.78 (1.50–2.11) |
| 1 variant | 9 (1628/3942) | 1.40 (1.19–1.65) | 0.24 | 22.7 | 4 (670/650) | 1.54 (1.29–1.85) |
| 2+ variants | 8 (737/1030) | 1.80 (1.49–2.17) | 0.001 | 70.5 | 4 (404/234) | 2.49 (1.99–3.12) |
| Scoreb 1 | 8 (776/2043) | 1.24 (1.02–1.51) | 0.27 | 19.2 | 4 (350/371) | 1.41 (1.15–1.73) |
| Scoreb 2 | 8 (1041/2183) | 1.61 (1.33–1.96) | 0.31 | 15.3 | 4 (422/354) | 1.81 (1.47–2.22) |
| Scoreb 3 | 8 (351/439) | 1.93 (1.52–2.46) | 0.001 | 69.5 | 4 (199/111) | 2.68 (2.01–3.57) |
| Scoreb ⩾4 | 8 (197/307) | 1.80 (1.37–2.38) | 0.02 | 57.5 | 4 (103/48) | 2.68 (1.81–3.96) |
|
BCC | ||||||
| Wild typea | 7 (937/4288) | Reference | — | — | 3 (322/506) | Reference |
| Any variant | 7 (1802/4666) | 1.39 (1.15–1.69) | 0.01 | 63.6 | 3 (924/787) | 1.75 (1.46–2.09) |
| 1 variant | 7 (1244/3720) | 1.31 (1.08–1.60) | 0.21 | 28.6 | 3 (581/588) | 1.52 (1.26–1.83) |
| 2+ variants | 7 (558/946) | 1.70 (1.36–2.12) | 0.002 | 70.8 | 3 (343/199) | 2.48 (1.96–3.15) |
| Scoreb 1 | 7 (610/1925) | 1.17 (0.94–1.46) | 0.26 | 22.8 | 3 (308/344) | 1.39 (1.12–1.72) |
| Scoreb 2 | 7 (786/2046) | 1.51 (1.21–1.87) | 0.27 | 20.5 | 3 (359/307) | 1.78 (1.43–2.21) |
| Scoreb 3 | 7 (264/399) | 1.80 (1.37–2.36) | 0.001 | 72.1 | 3 (176/91) | 2.85 (2.10–3.86) |
| Scoreb ⩾4 | 7 (142/296) | 1.62 (1.19–2.20) | 0.07 | 48.7 | 3 (81/45) | 2.36 (1.56–3.56) |
|
SCC | ||||||
| Wild typea | 5 (272/3783) | Reference | — | — | 2 (45/175) | Reference |
| Any variant | 5 (668/3881) | 1.61 (1.35–1.91) | 0.42 | 0 | 2 (192/333) | 2.17 (1.44–3.28) |
| 1 variant | 5 (452/3124) | 1.55 (1.24–1.94) | 0.70 | 0 | 2 (113/237) | 1.89 (1.22–2.92) |
| 2+ variants | 5 (216/757) | 2.10 (1.60–2.76) | 0.19 | 35.3 | 2 (79/96) | 2.80 (1.71–4.57) |
| Scoreb 1 | 5 (190/1561) | 1.23 (0.92–1.64) | 0.59 | 0 | 2 (51/120) | 1.51 (0.91–2.52) |
| Scoreb 2 | 5 (308/1755) | 1.94 (1.48–2.53) | 0.79 | 0 | 2 (80/145) | 2.28 (1.42–3.67) |
| Scoreb 3 | 5 (105/318) | 2.28 (1.59–3.28) | 0.11 | 46.5 | 2 (34/49) | 2.49 (1.37–4.54) |
| Scoreb ⩾4 | 5 (65/247) | 2.33 (1.50–3.61) | 0.10 | 48.2 | 2 (27/19) | 4.93 (2.28–10.64) |
Abbreviations: CI=confidence interval; MC1R=melanocortin-1-receptor; SOR=summary odds ratio.
Note: significant ORs and P-values are in bold.
a
For studies that did not sequence MC1R gene it includes both wild-type and carriers of any MC1R variant not specifically assessed in the original study.
b
Score calculated as detailed in Davies et al (2012).