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. 2015 Feb 24;8:9. doi: 10.1186/1756-8935-8-9

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© Gaddis et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ICG-001 and C646 affect many of the same genes in HCT116 and PANC1 cells. (A) Genes that were significantly detected in both HCT116 or in PANC1 cells (P value <0.01) were analyzed for expression differences caused by drug treatment. All genes having a differential P value <0.05 and a fold change greater than 1.2 were analyzed using Euclidean distance and hierarchical clustering. (B) Gene ontology analyses are shown for the genes commonly up- or downregulated in HCT116 and PANC1 cells by the drugs. Terms related to the cell cycle are shown in red. See Additional file 5 for a complete gene ontology analysis of the up- and downregulated genes.