Table 3.
Summary of the results for the comparison between IGlar and other insulin preparations
| Outcome | IGlar vs. NPH | IGlar vs. MIX | IGlar vs. IDet | ||||
|---|---|---|---|---|---|---|---|
| +OAD | +bolus ± OAD | IGlar: +OAD MIX: MT |
+OAD | IGlar: +bolus ± OAD MIX: +OAD |
+OAD | +bolus ± OAD | |
| Target HbA1c without hypoglycemia | |||||||
| Overall | n/a | n/a | n/a | No difference | n/a | No difference | FavoursIGlar |
| Nocturnal | FavoursIGlar | n/a | FavoursIGlar | No difference | n/a | n/a | n/a |
| Symptomatic | n/a | n/a | n/a | n/a | n/a | No difference | No difference |
| HbA1c reduction | No difference | No difference | FavoursIGlar | Favours MIX | No difference | No difference | FavoursIGlar |
| Target HbA1c | No difference | No difference | FavoursIGlar | Favours MIX | FavoursIGlar | No difference | FavoursIGlar |
| FPG reduction | FavoursIGlar | No difference | FavoursIGlar | No difference | No difference | FavoursIGlar | No difference |
| Target FPG level | No difference | No difference | FavoursIGlar | FavoursIGlar | No difference | FavoursIGlar | No difference |
| Body weight gain | No difference | No difference | No difference | FavoursIGlar | No difference | FavoursIDet | FavoursIDet |
| Treatment satisfaction (DTSQ) | FavoursIGlar | n/a | No difference | n/a | n/a | FavoursIGlar | n/a |
| Quality of life (DSC-R) | n/a | n/a | n/a | FavoursIGlar | No difference | FavoursIGlar | n/a |
| Overall hypoglycemia | No difference | No difference | FavoursIGlar | FavoursIGlar | No difference | No difference | No difference |
| Symptomatic hypoglycemia | FavoursIGlar | No difference | FavoursIGlar | FavoursIGlar | No difference | No difference | No difference |
| Severe hypoglycemia | No difference | No difference | No difference | No difference | No difference | No difference | No difference |
| Nocturnal hypoglycemia | FavoursIGlar | FavoursIGlar | FavoursIGlar | No difference | No difference | No difference | No difference |
| Overall AEs | No difference | No difference | No difference | No difference | No difference | n/a | No difference |
| AEs associated with treatment | No difference | No difference | No difference | No difference | FavoursIGlar | No difference | n/a |
| AEs: injection site reactions | No difference | No difference | n/a | n/a | n/a | FavoursIGlar | n/a |
| Withdrawals due to AEs | No difference | No difference | No difference | FavoursIGlar | No difference | FavoursIGlar | No difference |
| SAEs | No difference | No difference | n/a | FavoursIGlar | No difference | No difference | No difference |