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. Author manuscript; available in PMC: 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16;162(2):441–451. doi: 10.1016/j.cell.2015.05.056

Figure 4. Compound similarity inference, see also Figure S5.

Figure 4

(A) Compound similarity is assessed based on the statistical significance (by FET) of the overlap of their DeMAND-inferred MoA proteins.

(B) DeMAND-inferred compound similarity in the DP92 dataset is assessed by (a) the overlap of known direct targets between two compounds (orange), (b) compound sensitivity profile similarity based on CTD2 data (green), (c) overlap in compound classification, according to the Anatomical Therapeutic Chemical (ATC) Classification (blue), or (d) any of the above evidences (black).