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On premature translation termination, Upf1 and associated factors are recruited by stall ribosomes. At this stage, the helicase Upf1 (written in red) is inactive. Then, Upf1 joins Upf2 and Upf3 bound to an EJC to form the DECID complex is which Upf1 (written in green) is activated. Finally, being highly processive, Upf1 translocates toward the 3′-end extremity of the mRNA to remodel the mRNP leading to mRNA decay.
