Table 1. Kinetic parameters in euploid versus aneuploid embryos.
| All embryos |
Normal divisions |
Abnormal divisions |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Median | IQR | N | Median | IQR | N | Median | IQR | |
| PNd to first cytokinesis (h) | |||||||||
| Euploid | 22 | 2.4* | (2.1; 2.9) | 18 | 2.3‡ | (2.1; 2.9) | 4 | 2.9 | (0.9; 3.1) |
| Aneuploid | 26 | 2.8* | (2.5; 3.3) | 14 | 2.8‡ | (2.5; 3.3) | 12 | 2.9 | (2.5; 7.9) |
| First cytokinesis (min) | |||||||||
| Euploid | 22 | 15.0 | (13.8; 26.3) | 18 | 15.0 | (10.0; 21.3) | 4 | 25.0 | (16.3; 60.0) |
| Aneuploid | 26 | 20.0 | (13.8; 31.3) | 14 | 20.0 | (10.0; 31.3) | 12 | 22.5 | (15.0; 37.5) |
| Two to three cells (h) | |||||||||
| Euploid | 14 | 11.3 | (1.4; 12.2) | 10 | 11.7 | (11.1; 12.6) | 4 | 1.3 | (0.5; 4.3) |
| Aneuploid | 23 | 11.4 | (0.8; 12.6) | 11 | 12.5 | (11.8; 12.9) | 12 | 0.8 | (0.1; 2.4) |
| Three to four cells (h) | |||||||||
| Euploid | 12 | 0.8† | (0.2; 1.3) | 10 | 0.8 | (0.4; 1.3) | 2 | 5.4 | (0.1; NA) |
| Aneuploid | 20 | 2.4† | (0.9; 8.4) | 11 | 1.7 | (0.8; 2.7) | 9 | 4.4 | (1.6; 12.3) |
| Four to five cells (h) | |||||||||
| Euploid | 5 | 5.3 | (1; 13.8) | 4 | 8.8 | (2.9; 14.6) | 1 | 0 | (0; 11.2) |
| Aneuploid | 25 | 9.9 | (0.8; 12.3) | 6 | 12.8 | (11.7; 15.7) | 9 | 2.7 | (0.3; 9) |
| Five to six cells (h) | |||||||||
| Euploid | 5 | 7.2 | (1.4; 9.3) | 4 | 4.9 | (0.7; 7.4) | 1 | 11.2 | (11.2; 4.3) |
| Aneuploid | 12 | 1.6 | (0.4; 3.8) | 6 | 1.6 | (0.5; 2.7) | 6 | 1.6 | (0.3; 13.8) |
| Six to seven cells (h) | |||||||||
| Euploid | 4 | 1 | (0.6; 3.5) | 3 | 0.8 | (0.5; NA) | 1 | 4.3 | (4.3; 0.8) |
| Aneuploid | 12 | 2 | (1; 8.5) | 6 | 1.5 | (0.5; 3.9) | 6 | 5.1 | (1.2; 13.2) |
| Seven to eight cells (h) | |||||||||
| Euploid | 4 | 0.8 | (0.6; 1.1) | 3 | 0.8 | (0.5; NA) | 1 | 0.8 | (0.8; 0.5) |
| Aneuploid | 10 | 0.7 | (0.4; 3.4) | 6 | 1.5 | (0.4; 3.4) | 4 | 0.6 | (0.3; 4.9) |
| Eight to nine cells (h) | |||||||||
| Euploid | 1 | 0.5 | (0.5; 0.5) | 0 | NA | (NA; NA) | 1 | 0.5 | (0.5; NA) |
| Aneuploid | 2 | 2.5 | (1.6; NA) | 0 | NA | (NA; NA) | 2 | 2.5 | (1.6; NA) |
IQR, interquartile range (Q1; Q3); NA, not applicable; PNd, pronuclei disappearance.
Kinetic parameters were calculated for every aneuploid and euploid embryo (‘All embryos'). In addition, they were classified according to the type of divisions (‘Normal divisions' and ‘Abnormal divisions'), since one abnormal division may alter all subsequent kinetic parameters, which are calculated based on the cell stage of the embryo. *,†,‡P<0.05 (Mann–Whitney U-test).