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. 2014 Mar 20;20(18):5492–5500. doi: 10.1002/chem.201304929

Table 2.

In situ NMR monitoring data

Entry Acid4 Conversion4[%] Max yield5[%] tmax5[min] Max yield7[%] tmax7[min]
1 a 88 7 420 >1 540
2 b 100 47 180 3 240
3 c 100 46 540 3 540
4 d 100 59 240 3 300
5 e 100 94[a] 180 3 240
6 f 98 54[b] 240 1 240
7 g 99 98 240 3 240
8 h 5 240 240
9 i 98 41 180 4 240
10 j 80 39 420 2 540
11 k 41 18 540 >1 540
12 l 97 96 90 3 120

[a] Combined yield of 7-methoxy (76 %) and 9-methoxy (18 %) regioisomers. [b] Yield of 5 a (loss of MeO).