Table 2.
Entry | Acid4 | Conversion4[%] | Max yield5[%] | tmax5[min] | Max yield7[%] | tmax7[min] |
---|---|---|---|---|---|---|
1 | a | 88 | 7 | 420 | >1 | 540 |
2 | b | 100 | 47 | 180 | 3 | 240 |
3 | c | 100 | 46 | 540 | 3 | 540 |
4 | d | 100 | 59 | 240 | 3 | 300 |
5 | e | 100 | 94[a] | 180 | 3 | 240 |
6 | f | 98 | 54[b] | 240 | 1 | 240 |
7 | g | 99 | 98 | 240 | 3 | 240 |
8 | h | 5 | – | 240 | – | 240 |
9 | i | 98 | 41 | 180 | 4 | 240 |
10 | j | 80 | 39 | 420 | 2 | 540 |
11 | k | 41 | 18 | 540 | >1 | 540 |
12 | l | 97 | 96 | 90 | 3 | 120 |
[a] Combined yield of 7-methoxy (76 %) and 9-methoxy (18 %) regioisomers. [b] Yield of 5 a (loss of MeO).