Table 3.
Distribution of the STAT3 rs744166 genotypes according to the gender, mean age, CagA status and EPIYA-C patterns in patients with gastritis and gastric cancer
| Disease | STAT3 genotypes | |||
|---|---|---|---|---|
| AA | AG | GG | Total | |
| n (%) | n (%) | n (%) | n (%) | |
| Gastritis (n = 275) | ||||
| Female | 61 (33.7) | 78 (43.1) | 42 (23.2) | 181 (65.8) |
| Male | 27 (28.7) | 36 (38.3) | 31 (33.0) | 94 (34.2) |
| Mean age in yrs (SD) | 49.6 (17.1) | 53.9 (18.6) | 58.6 (15.3) | 53.8 (17.6) |
| cagA -ve | 26 (25.7) | 49 (48.5) | 26 (25.7) | 101 (36.7) |
| cagA +ve | 62 (35.6) | 65 (37.4) | 47 (27.0) | 174 (62.3) |
| EPIYA-AB | 1 (25.5) | 1 (25.5) | 2 (50.0) | 4 (2.3) |
| EPIYA-ABC | 44(32.1) | 53 (38.7) | 40 (29.2) | 137 (78.7) |
| EPIYA-ABCC | 15 (53.6) | 8 (28.6) | 5 (17.8) | 28 (16.1) |
| EPIYA-ABCCC | 2 (40.0) | 3 (60.0) | 0 | 5 (2.9) |
| Gastric cancer (n = 232) | ||||
| Female | 19 (21.8) | 41 (47.1) | 27 (31.0) | 87 (37.5) |
| Male | 40 (27.6) | 61 (42.1) | 44 (30.3) | 145 (62.5) |
| Mean age in yrs (SD) | 63.4 (13.3) | 61.5 (12.9) | 61.7 (13.6) | 62.0 (13.2) |
| cagA -ve | 2 (10.5) | 11 (57.9) | 6 (31.6) | 19 (8.2) |
| cagA +ve | 57 (26.8) | 91 (42.7) | 65 (30.5) | 213 (91.8) |
| EPIYA- AB | 0 | 2 (66.7) | 1 (33.3) | 3 (1.4) |
| EPIYA-ABC | 28 (23.1) | 53 (43.8) | 40 (33.1) | 121 (56.8) |
| EPIYA-ABCC | 22 (30.1) | 30 (41.1) | 21 (28.8) | 73 (34.3) |
| EPIYA-ABCCC | 7 (43.8) | 6 (37.5) | 3 (18.7) | 16 (7.5) |
n, number; SD, standard deviation; yrs, years. -ve, negative; +ve, positive