Table 6.

Host and bacterium variables associated with gastric cancer (n = 213) in comparison with gastritis (n = 174) in patients infected by H. pylori cagA-positive strains

Covariates	Univariate analysis	Multivariate analysis
	p	OR	95 % CI	p
First modela
Age	< 0.001	1.04	1.02 - 1.05	< 0.001
Gender	< 0.001	3.58	2.10 - 6.09	< 0.001
rs744166	0.007	1.64	1.16 - 2.31	0.005
EPIYA-C number	< 0.001	2.28	1.41 - 3.68	0.001
Second modelb
Age	< 0.001	1.05	1.05 - 1.06	< 0.001
Gender	< 0.001	3.23	2.02 - 5.17	< 0.001
rs744166 plus EPIYA-C number	< 0.001	3.01	2.29 - 3.97	< 0.001

The Hosmer-Lemeshow tests showed good fit for models ^a(10 steps, 8 degrees of freedom; p = 0.42) ^b(10 steps, 8 degrees of freedom; p = 0.25), OR, odds ratio; 95 % CI: confidence interval. We constructed two models studying the loci, according to the amount of G rs744166 allele, treated as categorical variables having 3 values with 0 meaning the AA genotype, 1 the carrier of one G allele and 2 the GG genotype. In the second model the variable was obtained by the sum of the amount of STAT3 G allele and the number of EPIYA-C segments