Fig. 5.

The relative mitogenic potential of various insulin analogues determined by the classifier gene expression. MCF7-IGF1R cells were exposed to IGF1, X10, glargine, insulin, aspart, lispro, M1, glulisine, M2 and detemir and the gene expression of the mitogenic classifier genes was measured with RT-qPCR. A hierarchical clustering of the log2 fold changes (compared to vehicle stimulation) is shown. The mitogenic potential score is the absolute sum of the absolute values of log2 fold changes of the mitogenic classifiers. IGF1 insulin-like growth factor 1, IGF1R IGF1receptor