Fig. 7.

Correlation between mitogenic classifier score and the enhanced proliferation or IGF1R binding. a A correlation is presented of the mitogenic potential based on the mitogenic classifier analysis (x-axis) vs. the mitogenic potential as determined by other studies with proliferation assays. Sommerfeld et al. [16] expressed this score as EC50 value from their proliferation curves (left y-axis). Data from Kurtzhals et al. [41] are expressed as fold changes compared to insulin (right y-axis). b A similar correlation graph with the mitogenic potential from this study plotted against the IGF1R binding affinity according to two other studies. Sommerfeld et al. [16] expressed this score as IC50 value from their competition assay curves (left y-axis). Data from Kurtzhals et al. [41] are expressed as fold changes compared to the binding affinity of insulin toward the IGF1R (right y-axis) (data adapted from Kurtzhals et al. [41] and Sommerfeld et al. [16]). IGF1R insulin-like growth factor 1 receptor