. 2015 Apr 30;15:45. doi: 10.1186/s12890-015-0040-0

Table 2.

INSPIRE Main Study Schedule

Time Point	First year enrollment timeline	Second year enrollment timeline	Visit Type	Survey	Nasal	Urine	Fecal	LPS Wipe	Blood	Allergy
Enrollment Visit	June 2012 –Mar 2013	June 2013 – Mar 2014	Baseline	X	X*	X	X*		X maternal
Winter Virus Season	Nov 2012 –Mar 2013	Nov 2013 - Mar 2014	Biweekly Contact	X
			Multiple Respiratory Illness visits	X	X	X
Well Child Visits	June – Dec 2013	June – Dec 2014	1^st Annual Visit	X				X	X
	June – Dec 2014	June – Dec 2015	2^nd Annual Visit	X
		June 2015 –June 2016**	2-3 Year Sub-Study (n = 100)**	X	X		X		X PBMC**
	June – Dec 2015	June – Dec 2016	3^rd Annual Visit	X						X
	June – Dec 2016		4^th Annual Visit	X

*included in second year cohort enrollment only.

**Sub-study of microbiome on subset of children; PBMC = Peripheral Blood Mononuclear Cells.

Nasal = Filter paper at baseline and nasal wash at time of respiratory illness.

Blood = Maternal finger stick at baseline and infant venipuncture or finger/toe stick at 1 year.

Allergy = Skin prick testing for aeroallergens or venipuncture for serum allergen-specific IgE.