Table 2.

Biochemical and pharmacokinetic properties of SMM-189

Aqueous solubility	∼185 μg/mL at pH 7.4
cLogP	5.26
Membrane Permeability (log Pe)	−5.02 ± 0.02 cm/sec at pH 7.4
Microsomal stability (% of parent remaining)	45.3% at 90 min
Plasma protein binding	99.37 ± 0.01% at 500 ng/mL
	99.84 ± 0.02% at 2 μg/mL
Terminal half-life	3.03 ± 0.49 h
Volume of distribution	14.9 ± 2.38 L/kg

SMM-189, 3′,5′-dichloro-2,6-dihydroxy-biphenyl-4-yl)-phenyl-methanone