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. Author manuscript; available in PMC: 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 2;162(2):259–270. doi: 10.1016/j.cell.2015.06.017

Figure 6. mTORC1 Suppresses Lysosomal Degradation of Internalized Proteins.

Figure 6

(A) Time-course of lysosomal DQ-BSA degradation in K-RasG12D MEFs in the presence or absence of 250 nM torin 1. (B) Quantification of DQ-BSA fluorescence of cells shown in (A). (C) Lysosomal degradation of DQ-BSA in wild type and K-RasG12D MEFs after 6 h DQ-BSA uptake in the presence or absence of 250 nM torin 1. (D) Quantification of DQ-BSA fluorescence of cells shown in (C).

Data are represented as mean ± STDEV (n ≥ 5 fields of view with > 20 cells each). * p < 0.05, *** p < 0.001. Scale bars = 20 μm. See also Fig. S6.