Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
As a cofactor, ascorbate participates in the cascade oxidation of 5mC, to 5hmC, to 5fC and to 5caC catalyzed by TET dioxygenases. 5fC and 5caC are then replaced by unmodified 5C by BER machinery. Additionally, unable to maintain 5hmC in the newly synthesized DNA also leads to passive demethylation. The methylation of an unmodified 5C could be reestablished by DNMT1, thus complete a cycle of DNA methylation–demethylation.
