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. Author manuscript; available in PMC: 2015 Jul 18.
Published in final edited form as: Annu Rev Nutr. 2015 May 6;35:545–564. doi: 10.1146/annurev-nutr-071714-034228

Figure 2. The role of ascorbate in histone demethylation.

Figure 2

As a cofactor for Jmjc domain-containing histone demethylases (JmjC), ascorbate participates in the oxidation of tri-methylated, di-methylated and mono-methylated lysine in histones, which is followed by a spontaneous removal of the hydroxymethyl group. The methylation of an unmodified lysine in histones could be reestablished by HMT, thus complete a cycle of histone methylation–demethylation.