Table 5.
Association of Nonvertebral Fracture (Fx) With Quartiles of 25OHD or 1,25(OH)2D (HR, 95% CI) (n = 1000)
| Fx (n) | Base modela | Model 2b | Model 3c | Model 4d | |
|---|---|---|---|---|---|
| 25OHD (ng/mL) | |||||
| Per SD increase in vitamin D | 0.97 (0.87, 1.09) | 1.01 (0.90, 1.13) | 1.02 (0.90, 1.15) | 1.01 (0.90, 1.13) | |
| Q1 (3.13–20.90) | 131 | Referent | Referent | Referent | Referent |
| Q2 (20.91–25.90) | 118 | 0.90 (0.70, 1.16) | 0.93 (0.72, 1.21) | 0.94 (0.72, 1.22) | 0.94 (0.73, 1.22) |
| Q3 (26.00–31.00) | 106 | 1.10 (0.84, 1.44) | 1.17 (0.89, 1.53) | 1.18 (0.90, 1.54) | 1.17 (0.90, 1.54) |
| Q4 (31.10–55.80) | 76 | 0.95 (0.70, 1.29) | 1.04 (0.77, 1.41) | 1.05 (0.77, 1.44) | 1.04 (0.77, 1.41) |
| p for trend | 0.84 | 0.43 | 0.39 | 0.43 | |
| 1,25(OH)2D (pg/mL) | |||||
| Per SD increase in vitamin D | 1.02 (0.92, 1.13) | 0.99 (0.89, 1.10) | 0.99 (0.88, 1.10) | 0.99 (0.89, 1.10) | |
| Q1 (8.70–51.60) | 108 | Referent | Referent | Referent | Referent |
| Q2 (51.70–62.00) | 98 | 0.90 (0.68, 1.19) | 0.88 (0.66, 1.16) | 0.87 (0.66, 1.15) | 0.88 (0.67, 1.16) |
| Q3 (62.10–75.10) | 116 | 1.04 (0.79, 1.36) | 0.97 (0.74, 1.27) | 0.95 (0.72, 1.25) | 0.97 (0.74, 1.27) |
| Q4 (75.20–142.00) | 110 | 1.02 (0.77, 1.35) | 0.94 (0.71, 1.25) | 0.93 (0.69, 1.25) | 0.94 (0.71, 1.25) |
| p for trend | 0.68 | 0.86 | 0.70 | 0.83 | |
a
Base model adjusted for age, race, site, season, physical activity, height, and weight.
b
Model 2 = Base model adjusted for baseline hip BMD.
c
Model3 = Model 2 adjusted for other vitamin D measure; that is, the 25OHD association is adjusted for 1,25(OH)2D and vice versa.
d
Model 4 = Model 2 adjusted for incident falls in the first year of follow-up.