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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Bone Miner Res. 2015 May 22;30(8):1468–1480. doi: 10.1002/jbmr.2488

Figure 3.

Figure 3

Tibial metaphyseal bone mass was reduced in pOC-ERαKO female mice but increased in pOC-ERαKO male mice, and pOC-ERαKO female mice responded more to 2 weeks of tibial compression. Representative transverse 3D microCT reconstructions (0.51mm thick) of the tibial metaphysis in (A) female and (D) male 12-week-old LC (top) and pOC-ERaKO mice (bottom) after 2 weeks of left tibial loading. (B) BV/TV of cancellous bone in female pOC-ERaKO mice was 25% lower in the unloaded right tibia compared to LC. After two weeks of tibial loading, BV/TV increased more (+97%) in pOC-ERaKO mice than in LC mice (+43%). (E) BV/TV was increased in the tibial metaphysis of male pOC-ERaKO compared to LC, but 2 weeks of loading did not alter BV/TV in left vs. right limbs for either genotype. (C,F) Area of the cortical shell increased similarly between genotypes within each sex after loading, and Ct.Ar was unaffected by ERα deletion in both sexes.

BV/TV, bone volume fraction; Ct.Ar, cortical area. Data are mean ± SD, n=12–14 per group. †Loaded tibia different from Control, p<0.05 by repeated measures ANOVA with interaction for each sex. Bars not sharing same letter are significantly different from one another from Tukey HSD post-hoc only when interaction term (load*genotype) was significant. Scale bar = 1.0mm.