Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Bone Miner Res. 2015 May 22;30(8):1468–1480. doi: 10.1002/jbmr.2488

Figure 4.

Figure 4

(A) Two weeks of loading increased matrix-secreting N.Ob/BS in the cancellous tibial metaphysis in both genotypes and sexes. In female mice, (B,E) MAR and (C,F) BFR were increased with loading, and MAR increased more in pOC-ERαKO than in LC mice (B,E). In male mice, MAR and BFR were not affected by tibial loading. (D) N.Oc/BS increased after loading in male but not female mice.

Matrix-secreting N.Ob/BS, number of osteoblasts staining positively for pro-collagen I normalized to bone surface; N.Oc/BS, number of osteoclasts staining positively for TRAP normalized to bone surface; MAR, mineral apposition rate; BFR, bone formation rate. Data are mean ± SD, n=6–7 per group. *pOC-ERαKO different from LC, †Loaded tibia different from Control, p<0.05 by repeated measures ANOVA with interaction for each sex. Bars not sharing same letter are significantly different from one another from Tukey HSD post-hoc only when interaction term (load*genotype) was significant.