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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Bone Miner Res. 2015 May 22;30(8):1468–1480. doi: 10.1002/jbmr.2488

Table 2.

Female 10-week-old pOC-ERαKO mice responded more to 2 weeks of tibial compression than LC while male pOC-ERαKO mice responded similarly to LC, measured by microCT in the proximal tibia and tibial midshaft.

Female Male
LC pOC-ERαKO LC pOC-ERαKO
Cancellous Metaphysis BV/TV Control 0.0779 ± 0.019b 0.0584 ± 0.0095c 0.121 ± 0.041b 0.162 ± 0.037*a
Loaded 0.111 ± 0.014†a 0.115 ± 0.015†a 0.143 ± 0.030ab 0.156 ± 0.016*ab
Tb.Th (μm) Control 48.4 ± 2.4c 46.4 ± 2.2*c 46.0 ± 5.2c 52.4 ± 5.6*b
Loaded 67.3 ± 4.4†b 74.2 ± 4.2*†a 58.7 ± 3.0†a 61.0 ± 5.7*†a
Tb.Sp (μm) Control 323 ± 35 413 ± 41* 227 ± 28 225 ± 36
Loaded 327 ± 32 436 ± 52* 225 ± 31 230 ± 36
Tb.N Control 3.16 ± 0.36 2.52 ± 0.23* 4.46 ± 0.49 4.55 ± 0.63
Loaded 3.09 ± 0.26 2.39 ± 0.25* 4.41 ± 0.61 4.41 ± 0.59
cn.TMD (mg HA/cc) Control 767 ± 13 757 ± 14 765 ± 9.1 774 ± 15
Loaded 798 ± 12† 791 ± 15† 796 ± 11† 794 ± 13†
Cortical Shell Metaphysis Ct.Ar (mm2) Control 0.964 ± 0.092b 0.866 ± 0.050b 1.11 ± 0.12 1.18 ± 0.14
Loaded 1.28 ± 0.097†a 1.27 ± 0.049†a 1.31 ± 0.084† 1.39 ± 0.11†
Ct.Th (mm) Control 0.141 ± 0.010b 0.128 ± 0.0049*c 0.134 ± 0.013 0.141 ± 0.015
Loaded 0.179 ± 0.011†a 0.174 ± 0.0090*†a 0.156 ± 0.0076† 0.158 ± 0.0082†
IMAX (mm4) Control 0.373 ± 0.055 0.339 ± 0.032 0.553 ± 0.086 0.613 ± 0.11*
Loaded 0.534 ± 0.070† 0.540 ± 0.047† 0.670 ± 0.063† 0.771 ± 0.12*†
IMIN (mm4) Control 0.301 ± 0.040b 0.268 ± 0.035*c 0.421 ± 0.061b 0.440 ± 0.061b
Loaded 0.433 ± 0.061†a 0.429 ± 0.037*†a 0.530 ± 0.064†a 0.598 ± 0.085†a
ct.TMD (mg HA/cc) Control 833 ± 23 816 ± 19 817 ± 11 815 ± 14
Loaded 843 ± 20† 883 ± 12† 827 ± 17 815 ± 7.8
Cortical Midshaft Ct.Ar (mm2) Control 0.560 ± 0.029c 0.534 ± 0.026c 0.769 ± 0.080 0.823 ± 0.053*
Loaded 0.717 ± 0.034†b 0.755 ± 0.042†a 0.791 ± 0.049† 0.834 ± 0.052*†
Ma.Ar (mm2) Control 0.333 ± 0.017 0.348 ± 0.021 0.432 ± 0.029b 0.450 ± 0.024* ab
Loaded 0.317 ± 0.028† 0.325 ± 0.027† 0.420 ± 0.030b 0.465 ± 0.031*a
Ct.Th (mm) Control 0.205 ± 0.0095b 0.194 ± 0.0062b 0.241 ± 0.018 0.249 ± 0.012
Loaded 0.253 ± 0.011†a 0.258 ± 0.013†a 0.246 ± 0.008 0.248 ± 0.0072
IMAX (mm4) Control 0.0603 ± 0.0054c 0.0598 ± 0.0065*c 0.121 ± 0.022 0.141 ± 0.017*
Loaded 0.0926 ± 0.0098†b 0.105 ± 0.0089*†a 0.127 ± 0.017† 0.1474 ± 0.020*†
IMIN (mm4) Control 0.0505 ± 0.0034b 0.0470 ± 0.0046b 0.0849 ± 0.014 0.0936 ± 0.010*
Loaded 0.0646 ± 0.0064†a 0.0687 ± 0.0057†a 0.0883 ± 0.010† 0.0985 ± 0.012*†
ct.TMD (mg HA/cc) Control 1020 ± 16 1020 ± 8.4 1040 ± 12 1050 ± 17
Loaded 1010 ± 18† 1010 ± 12† 1040 ± 11 1050 ± 10

Data are mean ± SD. BV/TV, bone volume fraction; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; cn.TMD, cancellous tissue mineral density; Ct.Ar, cortical area; Ma.Ar, marrow area; Ct.Th, cortical thickness; IMAX and IMIN, maximum and minimum moments of inertia; ct.TMD, cortical tissue mineral density

*

pOC-ERαKO different from LC,

†

Loaded tibia different from Control, p<0.05 by repeated measures ANOVA with interaction for each sex.

a,b,c

Groups not sharing the same letter are significantly different by Tukey HSD post-hoc where a > b > c. Post-hoc performed when ANOVA interaction term was significant.