Table 3.

Characteristics and Benefits Demonstrated to be Associated with Proposed Endpoints

	Characteristics		Associated Benefits
Proposed endpoint	Objective, Reliable, Verifiable	Simplicity	Decreased Symptom Burden	Better Function	Shorter Time to Durable GVHD Resolution and Withdrawal of Systemic Treatment	Improved Overall Survival
Response	Yes	No	Yes	Yes	No	Inconsistent
Failure-free survival	No†	Yes	Mixed	NT	Yes	Yes
Survival without progressive impairment	Yes	No	Yes	Yes	NT	NT
Patient reported outcomes	Yes	Yes	Yes	Yes	NT	Some
Composite scale	Yes	No	Yes	Yes	NT	NT

* NT: not tested

^†Decisions to change treatment are not adequately objective or reliable.