Table 1.

JC Virus-related Diseases and Control Patient Samples

HIV Serology	HIV- positive	HIV- negative*	Total	HIV- positive controls	HIV- negative controls	Total
JCV Disease	PML, JCV GCN	PML, JCV GCN, JCVE
Number of patients	61	16	77	52	42	94
Number of blocks	206	128	334	70	57	127

HIV, human immunodeficiency virus infection; JCV, JC virus; PML, progressive multifocal leukoencephalopathy; GCN, granular cell neuronopathy; JCVE, JCV encephalopathy.

^*Conditions predisposing to JCV-associated brain diseases in HIV-negative patients included: chronic lymphocytic leukemia (n = 4), multiple sclerosis treated with natalizumab (n = 1), idiopathic T-cell lymphocytopenia (n = 1), transplant recipient (n = 1), polycythemia vera and myelofibrosis (n = 1), polymyositis (n = 1), rheumatoid arthritis (n = 1), brain tumor distant from PML lesions (n = 1), other tumor (n = 2) and 3 patients for which information was not available. Controls: HIV-positive or HIV-negative control subjects.