Table 1.
Platelet response to eradication treatment in Helicobacter pylori-positive adult ITP patients
| References | Agea | Disease durationb | Bacterial eradication (%) | Platelet count before eradicationc | Platelet count post eradicationc | Complete response rated (%) | Study location (primary patient ethnicity) |
|---|---|---|---|---|---|---|---|
| Gasbarrini et al. (1998) [104] | 43 ± 14 | NR | 8/11 (73) | 95 ± 39 | 140 ± 34 | 8/8 (100) | Italy (Caucasian) |
| Jarque et al. (2001) [105] | 54 (17–80) | NR | 23/32 (72) | 58 ± 24 | 65 ± 32 | 3/23 (13) | Spain (Caucasian) |
| Kohda et al. (2002) [106] | 54 ± 14 | 41.2 ± 38.2 | 19/19 (100) | 67 ± 54 | 120 ± 50 | 12/19 (63) | Japan (Japanese) |
| Hino et al. (2003) [107] | 55 ± 15 | 78 ± 42.4 | 18/21 (86) | 37 ± 21 | 67 ± 54 | 10/18 (56) | Japan (Japanese) |
| Hashino et al. (2003) [108] | 53.2 ± 12.9 | 125.5 ± 77.1 | 13/14 (93) | 58 ± 30 | 99 ± 56 | 5/13 (38) | Japan (Japanese) |
| Ando et al. (2003) [109] | 58 ± 11 | 78.1 ± 65.1 | 27/29 (93) | 56 ± 24 | 93 ± 49 | 16/27 (59) | Japan (Japanese) |
| Michel et al. (2004) [110] | 52.5 ± 15.9 | 10 (1–21) | 14/15 (93) | 32 ± 15 | 66 ± 98 | 0/14 (0) | USA (Caucasian) |
| Takahashi et al. (2004) [54] | 54 ± 13 | 52.5 ± 6.4 | 13/15 (87) | 40 ± 27 | 101 ± 86 | 7/13 (54) | Japan (Japanese) |
| Sato et al. (2004) [111] | 62 (37–87) | 59.4 (6–264) | 27/32 (84) | 54 ± 17 | 110 ± 21 | 10/27 (37) | Japan (Japanese) |
| Ando et al. (2004) [112] | 62 (38–83) | NR | 15/17 (88) | 49 ± 26 | 168 ± 43 | 10/15 (67) | Japan (Japanese) |
| Nomura et al. (2004) [113] | NR | NR | 12/28 (43) | 29 ± 6 | 78 ± 11 | 15/28 (54) | Japan (Japanese) |
| Veneri et al. (2005) [114] | 57 (24–72) | NR | 41/43 (95) | 57 ± 23 | 122 ± 33 | 20/41 (49) | Italy (Caucasian) |
| Inaba et al. (2005) [115] | 57 (25–82) | 48 (6–180) | 25/25 (100) | 52 ± 26 | NR | 11/25 (44) | Japan (Japanese) |
| Stasi et al. (2005) [116] | 58 ± 13 | 25 ± 19 | 52/64 (81) | 42 ± 25 | 129 ± 61 | 17/52 (33) | Italy/UK (Caucasian) |
| Fujimura et al. (2005) [117] | 59 ± 14 | 98.2 ± 81.6 | 161/207 (78) | NR | NR | 101/161 (63) | Japan (Japanese) |
| Suzuki et al. (2005) [118] | NR | NR | 11/13 (85) | 55 ± 27 | 114 ± 90 | 6/13 (46) | Japan (Japanese) |
| Suvajdzic et al. (2006) [119] | 54 ± 13 | NA | 23/30 (77) | 68 ± 33 | 84 ± 45 | 6/23 (26) | Serbia (Caucasian) |
| Ahn et al. (2006) [120] | 56.8 ± 18.5 | NA | 15/15 (100) | 72 ± 45 | 69 ± 65 | 2/15 (13) | USA (Caucasian) |
| Sayan et al. (2006) [121] | 50.8 ± 16.2 | NA | 18/20 (90) | 39 ± 16 | 100 ± 63 | NA | Turkey (Middle Eastern) |
| Asahi et al. (2006/08) [49,122] | NR | NR | 26/26 (100) | 35 ± 13 | 114 ± 61 | 16/26 (62) | Japan (Japanese) |
| Kodama et al. (2007) [19] | 57.9 ± 14.3 | 57.9 ± 14.3 | 44/52 (85) | 40 ± 29 | NR | 27/44 (62) | Japan (Japanese) |
| Campuzano-Maya (2007) [123] | NR | NR | 26/29 (90) | 57 ± 38 | 198 ± 98 | 20/26 (78) | Colombia (South American) |
| Estrada-Gomez et al. (2007) [124] 3 | NR | NR | 14/14 (100) | NR | NR | NR | Mexico (Mexican) |
| Satake et al. (2007) [125] | NR | 65 (1–272) | 23/25 (92) | NR | NR | 12/23 (52) | Japan (Japanese) |
| Emilia et al. (2007) [126] | 58 ± 19 | 11.5 ± 6.4 | 34/38 (89) | 41 ± 24 | 134 ± 96 | 23/34 (68) | Italy (Caucasian) |
| Rostami et al. (2008) [127] | 29.2 ± 7 | 64.5 ± 49.5 | 62/71 (87) | 60.2 ± 18.14 | 140.5 ± 34 | 28/62 (45) | Iran (Middle Eastern) |
| Jackson et al. (2008) [128] | 47.5 | NR | 2/4 (50) | NR | NR | 3/4 (75) | Canada (Caucasian) |
| Tag et al. (2010) [129] | 55 (35–76) | 2.5 (0–27.1) | 23/23 (100) | 78 (6–96) | 100 (46–172) | 11/23 (48) | Korea (Korean) |
| Sato et al. (2011) [130] | 62 ± 13 | 42 ± 41 | 31/31 (100) | <100 | >130 | 18/31 (58) | Japan (Japanese) |
| Veneri et al. (2011) [131] | 52.2 (15–87) | 52.7 ± 116.1 | 11/12 (92) | 9.6 ± 4 | >100 | 6/12 (50) | Italy (Caucasian) |
| Payandeh et al. (2012) [132] | 38.2 | NR | 26/29 (90) | 49.5 ± 15 | 69 ± 21.9 | 15/26 (58) | Iran (Middle Eastern) |
| Gan et al. (2013) [133] | 50 (19–71) | 109 (36–216) | NR | 47.5 ± 12 | 64.5 ± 33.2 | 2/11 (18) | Malaysia (Malay/Chinese/Indian) |
| Takezako et al. (2013) [134] | 55 ± 21 | 19 ± 13 | 17/19 (89) | 65 ± 48 | 200 ± 140 | 5/17 (29) | Japan (Japanese) |
a
Mean or median (range).
b
Months, (mean ± SD) (median, range).
c
×109/L.
d
≥6 months.