Table 2.
Summary of significant negative global connectivity differences between participants who received methylphenidate (MPH) and those who did not (no-MPH) at a combined threshold of voxel p<0.001 uncorrected and cluster-level p<0.05, FWE corrected
| MNI coordinates (mm) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Contrast | MPH | no-MPH | Cluster size (mm3) |
z-score | X | Y | Z | Side | Identified region |
| MPH>no-MPH | – | – | 11124 | 4.4 | 39 | −28 | 61 | R | Pre-central G |
| – | – | 4.24 | 9 | −25 | 76 | R | Paracentral lobule | ||
| no-MPH>MPH | – | – | 6210 | 4.53 | −57 | −67 | 22 | L | Superior temporal S |
| – | – | 4.39 | −54 | −73 | 31 | L | Angular G | ||
| – | – | 9990 | 4.33 | −21 | 53 | −2 | L | Frontal marginal G | |
| – | – | 3.96 | 24 | 47 | 4 | R | Middle frontal/anterior cingulate G |
||
| – | – | 5940 | 4 | 42 | −61 | 31 | R | Angular G | |
| – | – | 3.96 | 42 | −67 | 40 | R | Inferior parietal G | ||
| – | – | 3.89 | 54 | −70 | 25 | R | Middle temporal G | ||
R- right, L- left; G- gyrus; S- sulcus; −/− indicates significance of the negative connectivity.