Fig.4. Adenovirus-induced cytokine release is dependent on β₃ integrins.

WT and β₃^−/− female mice were injected IP with dl922-947 (10¹⁰particles) or with vehicle (n=4-7).

A. Hexon immunohistochemistry in murine spleens. Scale=50μm.

B. qRT-PCR analysis of murine spleen. Expression at 3 hours is shown relative to 0 hours and WT and β₃^−/− mice are compared. Samples were analysed in triplicate and data are presented as mean±SD (*p<0.05, ***p<0.001). KC=keratinocyte chemoattractant

C. Cytokine protein in murine serum post. Concentration at 3 hours is shown relative to 0 hours. WT and β₃^−/− mice are compared. Samples were analysed in triplicate and data are presented as mean±SD (*p<0.05, **p<0.01). KC=keratinocyte chemoattractant